Determination of acute toxic effects in mice following exposure to methyl bromide
Type de document : Tiré à part
Auteur(s) : ALEXEEFF (G.V.) | KILGORE (W.W.) | WATT (D.) | MUNOZ (P.)
Edité par [New York] : Hemisphere Publishing Corporation, 1985
- 1985
- Note
- Extr. de : Journal of toxicology and environmental health, 1985, n. 15, p. 109-123.
- Description physique
- 15 f. ; 30 cm.
- Date de publication
- 1985
- Résumé
- Résumé des auteurs : An inhalation system was designed and constructed for acurate nose exposure of mice to methyl bromide. Animals were exposed for 1 h to concentrations ranging from 0.87 to 5.93 mg/l. Mice exposed to concentrations up to 1.72 mg/l did not exhibit any indication of developing a toxic response. Animals exposed to concentrations of 2. 20 and 2.70 mg/l exhibited signifcantly decreased lung and liver weights when compared to controls. Animals exposed to concentrations above 3.50 mg/l exhibited kidney lesions. At concentrations of 3. 82 mg/l and above, animals exhibited abnormal clinical signs, weight loss, and mortality. In addition, at 4.70 mg/l, a liver lesion was observed. At concentrations above 5.77 mg/l, pathological changes were observed in the color and a decreased motor coordination was evident. Methyl bromide exposures of up to 3.82 mg/l did not affect the ability of mice to recall a single-task passive-avoidance test. The 1-h LC50 of methyl bromide in mice via inhalation was determined to be 4.68 mg/l (approximately 1200 ppm). The dose-response curve was quite steep and the LC10 to LC90 range of mortality was contained within a doubling of concentration.
- Citer la référence
- ALEXEEFF (G.V.) , KILGORE (W.W.) , WATT (D.) , MUNOZ (P.), Determination of acute toxic effects in mice following exposure to methyl bromide, [New York] : Hemisphere Publishing Corporation, 1985, 1985
